Cells employ control strategies to maintain a stable size. Dividing at a target size (the “sizer” strategy) is thought to produce the tightest size distribution. However, this result follows from phenomenological models that ignore the molecular mechanisms required to implement the strategy. Here we investigate a simple mechanistic model for exponentially growing cells whose division is triggered at a molecular abundance threshold. We find that size noise inherits the molecular noise and is consequently minimized not by the sizer but by the “adder” strategy, where a cell divides after adding a target amount to its birth size. We derive a lower bound on size noise that agrees with publicly available data from six microfluidic studies on Escherichia coli bacteria.

• Received 24 March 2023
• Accepted 12 February 2024
• Corrected 24 April 2024

DOI:https://doi.org/10.1103/PhysRevLett.132.098403